Synthesis and Antiviral Activities of Chiral Thiourea Derivatives

An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF6.The ionic solvent Call be recovered and reused without any loss of its activity.The target compounds were characterized by elemental analysis,IR,1H NMR and 13C NMR spectral data.Accord-ing to the preliminary bioassay,some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L.Title chiral compound 3i Was found to possess good in vivo protection,inactivation and curative activities of 57.O%,96.4%and 55.0%,respectively against TMV with an inhibitory concentration at 500 mg/L.The title chiral compound 3i revealed better inactivation effect on TMV(EC50=50.8pg/mL)than Ningnanmycin(EC50=60.2μg/mL).

作 者： YAN,Zhikun CAI,Xuejian YANG,Xuan SONG,Baoan CHEN,Zhuo BHADURY,S.Pinaki HU,Deyu JIN,Linhong XUE,Wei LU,Ping   作者單位： Center for Research and Development of Fine Chemicals,Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering,Guizhou University,Guizhou,Guiyang 550025,China  刊 名： 中國化學（英文版）  SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY  年，卷(期)： 2009 27(3)  分類號： O6  關鍵詞： chiral thiourea   ionic liauid gvnthesis antiviral activitv  

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